Ithuriel was laid down as Gayret for the Turkish Navy by Vickers Armstrong at their Barrow-in-Furness shipyard on 24 May 1939, but it was taken over by the Royal Navy at the outbreak of the Second World War whilst still under construction. She was launched on 15 December 1940 and commissioned on 3 March 1942. In the Second World War, she took part in Operation Harpoon & Operation Pedestal, the escorting of convoys to Malta in June & August 1942. During Operation Pedestal, she depth charged & rammed the Italian submarine Cobalto, causing the submarine to sink.
Ithuriel was attacked by German aircraft at Bone in Algeria on the night of 27–28 November 1942 and damaged beyond repair. On 29 November, she was beached &temporary repairs were started. In January 1943, repairs proceeded enough to allow for towing. On 27 February, the destroyer was towed to Algiers for survey. In March, Ithuriel was declared beyond local repair and laid up at Algiers.
In August, she was prepared for tow to Gibraltar. On 18 August, she sailed under tow from Algiers to Gibraltar. That September Ithuriel was placed in care and maintenance for use at Gibraltar. In October, she was deployed at Gibraltar for accommodation & training duties.
In July 1944, the vessel was prepared for tow to the United Kingdom. On 1 August, Ithuriel began her passage to Plymouth under tow by the tug Prosperous. On 8 August, she was paid off on arrival at Plymouth and placed on the Disposal List. The destroyer was sold to the British Iron & Steel Corporation for demolition by P & W McLellan. On 11 August, Ithuriel made her final voyage to Bo'ness, near Edinburgh. She arrived on 13 August at the breaker's yard. (Discrepancy in records as to whether she was sold for scrap in 1944 or 1945.)